The Indian Mutiny broke out at Meerut on May 10th 1857. As soon as the news reached England, reinforcements including the 1st Battalion, The Royal Fusiliers, were hurried out. This was the first appearance of the Regiment in India: they actually saw little action as they were sent to occupy the Punjab to ensure that the population remained passive.
They did however take part in occasional campaigns along the Northwest Frontier such as that at Umbeyla in 1863.

The Fusiliers also saw action in Canada (1866-67), Afghanistan (1880) and Egypt (1882-86).